Prognostic factors of hematologic recovery in nonchemotherapy drug-induced agranulocytosis.

We studied several factors that may influence the duration of hematologic recovery to reach neutrophil counts (>0.5 and 1.5×109/L) and thus, indirectly, the prognosis in 91 patients with well-established drug-induced agranulocytosis. Multivariable analysis showed that neutrophil count <0.1×109/L and infection profile (severe infections or septic shock) adversely influenced the neutrophil recovery (for the 2 neutrophil levels). Hematopoietic growth factors were significantly associated with rapid hematologic recovery (for the 2 neutrophil levels). Documented infection and antiplatelet agent-induced agranulocytosis were associated with rapid hematologic recovery (for a neutrophil count >1.5 ×109/L).